We want to be a pioneer company in the oral care  

Lipart Farma is a family-run business located in the Apulia region, south Italy.

We have tailored a brand new product called Melos® gel in the treatment of oral disease.

In light of the growing evidence, researchers are attempting to understand how the body naturally "turns off" inflammation. Melatonin (N-acetyl- 5- methoxytryptamine) is one such powerful hormone derived from an essential amino acid tryptophan [1]. Pinealocytes take up tryptophan from the blood and convert it into serotonin through hydroxylation and decarboxylation. Melatonin is released throughout the night by means of postsynaptic activation of the β-adrenergic receptors.

It has various local and systemic functions playing a critical role in controlling inflammatory reactions. It is predominantly synthesised and secreted from pineal gland and other extrapineal sources like retina, gastrointestinal tract, lens and immune system cells [2].

The effects of melatonin were described in 1917 but were first isolated from bovine pineal gland and structurally identified in 1958 by Lerner and colleagues[3]. Melatonin derives its name from serotonin, based on its ability to blanch the skin of amphibians [4].

The unique, highly lipophilic nature of melatonin makes it accesible to every cell. It is found in high concentrations in the bone marrow, intestine, and at the subcellular level in the mitochondria and nucleus [5].

Recently, its presence is detected in saliva and gingival crevicular fluid. Melatonin is said to play a significant role in protecting the oral cavity through its antioxidant, immunomodulatory, oncostatic, and other functions[6].

Melatonin may contribute to the regeneration of alveolar bone through the stimulation of type I collagen fiber production and the modulation of osteoblastic and osteoclastic activity.Thus treatment with topical melatonin was associated with an improvement of periodontal disease. Diseases of the periodontium are known to be aggravated by free radicals and by alterations in the immune response to microorganisms that are present in plaque [7].

Lipart Farma aims to be a pioneer in all its endeavors and set benchmarks in the oral hygiene.

  • To achieve leadership status in the sector.
  • To be a customer-first and quality-obsessed company.
  • To ensure well-being of all persons using our products.
  • To satisfy all customer request 

Melos gel is an innovative product and introduces a new idea in the oral care.

It quickly counteracts the inflammatory status of a diseased mouth.

Melos gel contains 2% of Melatonin plus essential oils and chlorexidine (0,12%) and the INCI formula is patented.

We recommend to use it once daily before going to sleep.

In severe pathology it can be used several times or according to the physician's prescription.

Apply a layer of Melos on the affected area using a cotton fioc or a fingertip.

The only and well documented effect of Melos gel is drowsiness.

Drowsiness is due to Melatonin. So if your work needs attention, apply it only night-time.

Recently we've added the Mentha Piperita oil.

Melos gel is produced in Italy. The contractor production site works in compliance with the ISO 9001-2015, ISO 13485 - 2016 and GMP ISO 22716-2007 standard.


[1] A. Kalsbeek, BuiJs, "Output pathways etc", Cells and tissue research, vol. 309, no.1, pp.109-118, 2002.

[2] Claustrat,Brun,Chazot, " The basic physiology and patophysiology of melatonin", Sleep medicine review, vol.9, no. 1, pp. 11-24, 2005.

[3] Lerner,Case, "Isolation of melatonin, the pineal gland factor that lightens melanocytes", Journal of the American chemical society, vol. 80, no. 10, p. 2587, 1958.

[4] Cord, Allen, "Evidence associating pineal gland function with alterations in pigmentation", Journal of Experimental Zoology, vol. 23, no. 1, pp. 207-224,1917.

[5] Reiter,Paredes, "Reducing oxidative/nitrosative stress newly discovered gene for melatonin", Critical reviews in Biochemestry and Molecular biology, vol. 44, no.4, pp. 175-200, 2009.

[6] e [7] Cutando, Gomez-Moreno, Arana, "Melatonin:potential functions in the oral cavity", Journal of Periodontology, vol. 78, no.6, pp.1094-1102, 2007.

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